Clinical and therapeutic aspects of systemic candidiasis ab 48.99 € als Taschenbuch: study of 60 cases in Neonatal Intensive Care Unit. Aus dem Bereich: Bücher, Wissenschaft, Medizin,
Clinical and therapeutic aspects of systemic candidiasis ab 48.99 EURO study of 60 cases in Neonatal Intensive Care Unit
The aim of this study was to describe the clinical, etiological and therapeutic aspects of systemic candidiasis in 60 infants hospitalized in Neonatal Intensive Care Unit (NICU), during a 10-year period. An observational study was carried out during the period from 1994 to 2003. In this decade there were 3219 admissions to the NICU. Sixty newborns (1.8% of cases) developed systemic candidiasis, observing the wide variation of 0.8% in 1995 to 5.2% in 2002. Candida species identified were C.albicans (83.3%), C. tropicalis (6.7%), C.parapsilosis (5%) and C.glabrata (1.7%). Low birth weight occurred in 63.3% of the newborns, with 50% of them weighing 1500 g and, among those, 23.3% weighed 1000g. Signs and symptoms most frequently observed at the time of suspicion of systemic candidiasis were respiratory abnormalities, abnormal temperature (hypothermia and hyperthermia), lethargy, hepatomegaly and splenomegaly. Multisystemic complications were frequent and severe, with high mortality (33.3%), significantly associated with the occurrence of pneumonia or thrombocytopenia.
Recurrent vulvovaginal candidiasis and vulvar vestibulitis have become common in young women during the last two decades. 10-15 % of all women of fertile have vulvar symptoms such as itching, dryness, soreness or dyspareunia at some point of their lives, causing severe impact on relationships and quality of life. As much as 5 to 8% of women of reproductive age suffer from recurrent episodes of vulvovaginal candidiasis. 75 % of women with vestibulitis report a history of recurrent candida infections. The causes for these two linked vulvovaginal disorders remain largely unclear. The main purposes of this academic thesis were to study aspects of lifestyle, such as chronic mental stress and intake of glucose, in relation to recurrent vulvovaginal candidiasis and vulvar vestibulitis, with the aim to recommend preventive strategies. The results could be of interest for any woman with recurrent genital candida or vulvar vestibulitis, as well as their health care providers.
The existing antifungals are becoming resistant infectious disease and urgent need is to diversity new antimicrobial compound with diverse chemical structure and novel mechanism of action of newly diagnosed and re-emerging infectious disease.The current study aims at investigating in vitro antifungal activity of Q. infectoria galls extract against C. albicans and to design and to formulate an stable, efficacious, easy to administer and safe local oromucosal drug delivery system of Quercus infectoria galls extract. Various two gelling agents were evaluated for their potential to oral gel the Q. infectoria galls extract, physicochemical characteristics and antifungal activity of the Q. infectoria galls extract-based oral gel was determined through different aspects including pre-formulation aspects, formulation aspects and post-formulation aspects. The results indicate the importance of herbal formulation in treatment of disease conditions like oral candidiasis.