Clinical and therapeutic aspects of systemic candidiasis ab 48.99 € als Taschenbuch: study of 60 cases in Neonatal Intensive Care Unit. Aus dem Bereich: Bücher, Wissenschaft, Medizin,
Clinical and therapeutic aspects of systemic candidiasis ab 48.99 EURO study of 60 cases in Neonatal Intensive Care Unit
Asian swamp eel is a freshwater eel covered with a thick layer of mucus. The aim of this study is to evaluate the therapeutic activity of eel skin mucus in-vivo. For in-vivo study, a topical gel delivery system used from eel skin mucus formulated gel to apply into the infected rat skins. Sprague Dawley rats were divided into normal, positive control, negative control, and treated groups. The infections were introduced to the rats by intracutaneous injections of pathogenic bacteria and fungi. The development of impetigo, tinea capitis and cutaneous candidiasis in the animal model was confirmed based on the clinical and histological observations. Following that, the infected rats were treated topically with the formulated gel from eel mucus extract. The histological analysis of the skin tissues which treated with the formulated gel was shown a complete recovery in the skin tissues at a similar rate as the control antibiotic groups. In conclusion, the present study revealed that eel skin mucus formulated gel efficient therapeutic candidate in treating skin infections which can be considered as a novel discovery as a natural alternative treatment for certain skin diseases.
The increasing incidences of human candidiasis and its tendency to become resistant to existing chemotherapies is a well-recognised health problem. Most frequently Candida infection occur in the person having pre-clinical complications such as HIV positive, cancer therapy, organ transplantation, diabetes, week immunity, using corticosteroids and broad spectrum antibiotics. Antifungal drugs currently used for the treatment of Candida infections include polyenes, azoles, echinocandins, allyamines, and flucytosine. These drugs exert either fungicidal or fungistatic activities by interfering with essential cellular processes. For over last two decade, azoles have been a mainstay of the antifungal therapy. Additionally, various biological properties of triazoles such as antineoplastic, antibacterial, analgesic, anti-inflammatory, antimalarial, anticonvulsant, etc have been reported which prompt researchers to explore these pharmacophore. This study includes the synthesis of some novel 1,2,3-triazole derivatives and evaluation of their biological properties against Candida cells
The aim of this study was to describe the clinical, etiological and therapeutic aspects of systemic candidiasis in 60 infants hospitalized in Neonatal Intensive Care Unit (NICU), during a 10-year period. An observational study was carried out during the period from 1994 to 2003. In this decade there were 3219 admissions to the NICU. Sixty newborns (1.8% of cases) developed systemic candidiasis, observing the wide variation of 0.8% in 1995 to 5.2% in 2002. Candida species identified were C.albicans (83.3%), C. tropicalis (6.7%), C.parapsilosis (5%) and C.glabrata (1.7%). Low birth weight occurred in 63.3% of the newborns, with 50% of them weighing 1500 g and, among those, 23.3% weighed 1000g. Signs and symptoms most frequently observed at the time of suspicion of systemic candidiasis were respiratory abnormalities, abnormal temperature (hypothermia and hyperthermia), lethargy, hepatomegaly and splenomegaly. Multisystemic complications were frequent and severe, with high mortality (33.3%), significantly associated with the occurrence of pneumonia or thrombocytopenia.
Candidiasis is the commonest fungal disease in human being. The causative agent of the disease is Candida albicans and non- albicans Candida. Candida has 163 acknowledged anamorphic species, present on the different habitat out of which following species are C. albicans, C. tropicalis, C. krusei, C. glabrata, C. guilliermondii, C. parapsilosis, C. lusitaniae, C. kefyr, C. rugosa, C. dubliniensis and C. viswanathii known to causing disease in human beings. The virulence factors of the C. albicans have the great role in the pseudohyphae formation by attached with epithelial cells and endothelial cells. Now a day various techniques like PCR, Candida Detection System, CAND-TEC and Dot Immunobinding Assay are available for detection of candidiasis from various clinical samples. The CHROM agar Candida is useful method to differentiate between the Candida albicans and other species of the genus Candida by the help of colonies colour of the Candida on culture plate. Keeping skin clean, dry, and free from abrasions or cuts can help prevent skin from Candidal infections. The animal pathogenicity of Candida has been observed in few animals like rabbit and mice.
Beside tuberculosis, awareness about chest disease is increasing and more non-tuberculosis lung infections are being recognized. Pulmonary Mycosis is not uncommon, a clinical study of pulmonary mycosis was undertaken in Nishtar Medical College and Hospital Multan, Pakistan. In our study the incidence of pulmonary mycosis is 8.2 percent among the patients suffering from respiratory diseases. The peak incidence was observed in the age group of 21-30 years. The incidence of pulmonary mycosis is 8.2 percent and statistically higher in male as compared to female (P0.01). Out of these 50 patients 38 were males and 12 females. Further scrutiny showed that 35 had candida albicans, 11 aspergillus and 4 mucormycosis. From the analysis of initial signs and symptoms and their modifications and investigations including radiological helped us in the diagnosis. No significance relation of occupation to pulmonary mycosis is detected in the present study. The disease was higher in urban population as compared to rural inhabitants and it was more in people with low income having poor living conditions. Candidiasis and Aspergillosis were found predominant in lower income group.
"Candida spp. Virulence and Diagnosis. Anti-Candidal Therapy" was written to provide comprehensive information on diseases caused by pathogenic yeasts. Candida species are the most common fungi involved in candidiases account for more than half of the cases. The presented information indicates that candidiasis remains an important clinical problem. Candida spp. colonize mucosal surfaces of healthy individuals. On the other hand, these yeasts as opportunistic pathogens cause serious diseases. In the book, the key virulence properties of Candida spp were discussed. We focused on Candida superficial and systemic infections as well as risk factors predisposing to candidiasis. Furthermore, our review outlines the virulence mechanisms which play a central role in the pathogenicity of Candida spp. Therapy of various forms of candidiasis as well as antifungal drug resistance are discussed in the book. Moreover, we emphasised that the resistant Candida strains present management problems for the clinicians. It is also apparent from our book that candidiasis has resulted in the need to develop concepts of new treatments.
This book is a practical, user-friendly guide to the clinical diagnosis and treatment of the oral mucosal lesions most frequently encountered in pediatric patients. For each entity, a characteristic clinical photograph is provided, the clinical appearance is concisely described, and guidance is offered on differential diagnosis and treatment options. Oral indications of systemic diseases are addressed in a separate section, and mucosal indicators of drug use, sexual abuse, and eating disorders are also identified.Oral lesions are a relatively common occurrence in the pediatric population. Fortunately, most of these lesions are transient and can be diagnosed clinically, examples include aphthous ulcers, traumatic ulcers, and lesions of infectious etiology such as viral lesions and candidiasis. There are also a number of mucosal lesions, such as mucoceles and viral papillomas, that require biopsy for diagnosis and/or surgical excision for treatment. This book will assist the practitioner in diagnosing and treating both transient and persistent mucosal lesions.